Minami K, Maruyama Y, Honbo M, Matsunaga J, Miyata K.
Abstract
PURPOSE: To evaluate laboratory models using accelerated aging to assess surface light scattering in hydrophobic acrylic intraocular lenses (IOLs).
SETTING: Miyata Eye Hospital, Miyazaki, Japan.
DESIGN: Experimental study.
METHODS: Acrysof SA60AT IOLs manufactured before optimization of the IOL production process (non-optimized IOLs) and Acrysof SN60WF IOLs that were manufactured after optimization of the production process (optimized IOLs) were examined. After the IOLs were accelerated aged corresponding to 0, 3, 5, 10, 15, and 20 years, surface light scattering was measured with a Scheimpflug camera. Formation of water aggregates below the IOL surface was observed with cryogenic focused ion-beam scanning electron microscopy.
RESULTS: In the non-optimized IOLs, surface light scattering increased with aging (P<.001, R2=0.87). There was no significant increase in surface light scattering in the optimized IOLs. An increase in water aggregates with sizes of nanometer order was observed in the aged non-optimized IOLs.
CONCLUSION: An in vitro model using accelerated aging was effective for examining the incidence of surface light scattering. The laboratory results showed suppression of surface light scattering in the IOL manufactured with the optimized process.
FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
J Cataract Refract Surg. 2014 Apr;40(4):652-6. doi: 10.1016/j.jcrs.2013.10.034.
PMID: 24680521 [PubMed - indexed for MEDLINE]